Description:
Some topical preparations for acne have been developed in the form of gels and creams. However, it is still rarely developed in the form of a patch dosage form. Waste from silkworm cocoons has the activity of inhibiting the growth of acne-causing bacteria, can be formulated into patch preparations. This study aims to formulate anti-acne patches from silkworm cocoon waste with variations of HPMC and PVP. The formulation of the anti-acne patch from silkworm cocoon waste was made by mixing the lyophilisate of silkworm cocoon waste with a patch base with variations of HPMC and PVP. The formulations were divided into 3 with different concentrations of HPMC and PVP additives, namely formulas 1 (4:1), 2 (2,3:1), and 3 (1:1), respectively, The evaluations carried out included organoleptic examination, patch thickness, weight uniformity, fold resistance, moisture absorption, drying shrinkage. The results obtained showed that the concentration of the combination of HPMC and PVP polymers in the patch preparation gave different results from all evaluations that had been carried out, including organoleptic evaluation, weight uniformity, fold resistance, and drying shrinkage were in accordance with the requirements of a good patch. The optimum concentration of the combination of HPMC and PVP as a polymer in the anti-acne patch preparation from silkworm cocoons is formula 2 with a ratio of (2,3:1) as novelty in this study

URL:
http://103.158.96.210:88/web_repository/uploads/36951-191998-1-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
MARIA ULFA