Description:
Shogaol and gingerol in ginger, can act as antiemetic. Ginger extract (Zingiber officinale Rosc. var Amarum) was formulated by patch transdermal to increase the effectiveness of therapy and to minimize the side effects. Method : maceration with ethanol 96% was used as extraction method and phytochemical screening was carried out to the extract to identfy the exctracted compounds. The formulation of transdermal patch used matrix method with ginger extract concentrations of 0.5(F1); 1.0 (F2); and 1.5 gram (F3). Evaluation of patch was carried out by organoleptic test, patch weight, thickness, tensile strength, elongation at break, modulus young, moisturizer test, and folding endurance. Effectiveness test used wistar mice by observed the pica response and a decreasing in kaolin consumption. The yield of the extract was 6.46% which contained essential oils, flavonoids, steroids and polyphenols. The best patch characteristics of the concentration was F3 with a patch weight of 0.39 g; thickness 0.23 mm; tensile strength 1.32 N/mm2; elongation at break 129.52%; young's modulus 0.96 mPa; humidity 1.32%; and folding endurance >200 times. F3 was the most effective formulation with 6% response of pica and 93.11% of decreasing in kaolin consumption observed in day 9.

URL:
http://103.158.96.210:88/web_repository/uploads/36518-177632-3-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
ARINI SYARIFAH