Description:
Oxcarbazepine (OXC) was used as first line therapy or additional therapy for treatment of partial and secondary of seizures. The penetration of OXC into nasal mucosa can be enhanced by forming liposome. This research has the aim to prepare and characterize iposome laoding OXC. The OXC liposome formula was composed by using soya lechitin and cholesterol with various amount using thin film hydration method. Characterization by determining the encapsulation efficiency (?), pH, viscosity, particle size, polydispersity of index, zeta potential, and in vitro release. The liposome of OXC was also analyzed for its stability based on heating-coling cycle method. The proportion of best formula was obtained at the amount of cholesterol of 42,11 mg yield ? of 92,63%, pH of 8,47, viscosity of 1,10 cP, and decreased amount of OXC in stability test of 0,34%. The results of particle diameter were 579 nm, polydispersity index (PDI) of 0,34, and zeta potential of -99,38 mV. The in vitro release of the liposome of OXC was studied and compared with OXC. The result of in vitro release liposome OXC (F2) ahowed increase (62,26%) than (41,97%).

URL:
http://103.158.96.210:88/web_repository/uploads/33707-177635-3-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
DINA P WIJAYA