Description:
Acne is an inflammatory condition of the pilosebaceous unit that can occur due to infection of Propionibacterium acnes. Rosemary essential oil contains various active compounds that have antibacterial activity. Nanoemulsions have been developed as a delivery system to the pilosebaceous unit. This study aimed to determine the antibacterial activity of rosemary oil against P. acnes and develop it into a nanoemulsion system. The antibacterial activity was conducted by the agar diffusion method. Rosemary oil contains 1,8-cineole as the main active compound and has antibacterial activity against P. acnes with an inhibitory zone of 11.315±0.069 mm at a concentration of 4%. Rosemary oil was successfully developed into a nanoemulsion system using Tween 80 as a surfactant and a combination of ethanol and PEG 400 as a co-surfactant. The rosemary nanoemulsion has a clear physical appearance with an average globule size of 33.50±0.01 nm and a PDI value of 0.45±0.03. The preparation has good physical stability based on centrifugation, heating cooling, and freeze-thaw tests. The study shows that rosemary oil has antibacterial activity against P. acnes and has been successfully developed into nanoemulsion preparations with good characteristics and physical stability.

URL:
http://103.158.96.210:88/web_repository/uploads/35770-170558-2-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
SANI E PRIANI