Description:
Context: Diclofenac sodium is a compound that belongs to the NSAIDs, it has pronounced anti-rheumatic, anti-inflammatory, analgesic and antipyretic properties. Objective: To carry out the design and optimization of the formulation of a diclofenac gel 1%. Methods: An experimental statistical design of D-Optimal mixtures was carried out, adjusted to a linear model, as well as the optimization of the formulation. The concentrations of carbopol 940, triethanolamine and isopropyl alcohol were selected as independent variables, as response variables pH and extensibility. They were determined at the beginning, 30, 60, and 90 days after the technological variants were elaborated. In addition, the viscosity and rheological behavior of the formulation selected as promising was determined, and the results were compared with those of the commercial product Voltaren® Gel. Results: The proportions of the pharmaceutical excipients and the values of the response variables considered in the best-selected formulation are very close to variant 2 of the experimental design. The selected formulation showed physical-chemical and technological properties in accordance with the requirements established for pharmaceutical gels and similar to the commercial product (Voltaren® Gel). Conclusions: The new formulation of diclofenac sodium gel 1% is similar to its commercial product and complies with the quality parameters studied for its technological development.

URL:
http://103.158.96.210:88/web_repository/uploads/no_data.jpg

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
Nilia de la Paz Martín-Viaña