Description:
The Pangandaran people process honje flowers into fresh drinks that are consumed for health. The forest honje leaf extract provides antidiabetic activity at a dose of 0.39 mg/g BW can reduce blood glucose levels by 36.16% has been reported. Limited scientific information from honje hutan flowers, it is necessary on its activity as an alpha-glucosidase inhibitor and study its chemical content. The extraction process was macerated in 70% ethanol for 24 hours and the fractionation process was carried out by liquid-liquid extraction method with n-hexane, ethyl acetate and water as solvents. Testing the activity of alpha-glucosidase inhibitors colorimetrically using the chromogenic substrate p-nitrophenyl ?-D-glucopyranoside, alpha-glucosidase enzymes derived from Saccharomyces cerevisiae, measurement of absorption at a maximum wavelength of 401.3 nm and acarbose used as a comparison drug alpha-glucosidase inhibitors. The results showed that the forest honje flowers contain flavonoids, polyphenols, tannins, quinones, monoterpenoids, and sesquiterpenoids. IC50 values for 70% ethanol extract, n-hexane, ethyl acetate, water and acarbose fractions were 136.79, 307.18, 277.12, 66.18, and 14.63 g/mL respectively. The water fraction gave the best inhibitory activity against alpha-glucosidase with an IC50 value of 66.18 g/mL.

URL:
http://103.158.96.210:88/web_repository/uploads/35453-170555-2-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
SORAYA RIYANTI