Description:
Diabetes mellitus is a degenerative disease characterized by an increase in blood sugar (hyperglycemia). Inhibiting it will prevent the uptake of glucose in the plasma. One of the plants that can be used as antidiabetic is E. crassipes herbs. This research aims to know the interaction between volatile chemical compounds from ethyl acetate fraction and ethanol fraction of ethanol extract of E. crassipes herbs with the ?-glucosidase enzyme. This study used ethanol extract of E. crassipes herbs with a variation of ethyl acetate fraction and ethanol fraction then analyzed the fraction using GC-MS (Gas Chromatography-Mass Spectroscopy). The ethyl acetate fraction contained 2-pyridine-propanoic acid, alpha.-methyl-.beta.-oxo-,Ethyl ester;1-propanol-1-di; carbamic acid, methyl ester; acetic acid, aminooxy-, hydrazide; (2R) - [2-2H2] glycine methyl ester hydrochloride. The ethanol fraction contained semicarbazide hydrochloride; carbonic dihydrazide; hydroxy-acetaldehyde; 1-propanol-1- di; acetic acid, and hydroxyl. The result of docking with the ?-glucosidase enzyme is 2-pyridinepropanoic acid, alpha.-methyl-.beta.-oxo-, the Ethyl ester of the ethyl acetate fraction having ?G is -4.14 Kcal/mol. Semicarbazide hydrochloride from the ethanol fraction has ?G of -3.17 Kcal/mol.

URL:
http://103.158.96.210:88/web_repository/uploads/32399-170551-2-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
DINIATIK