Description:
Effectiveness is the extent to which a drug can achieve the desired effect in clinical practice, in this case, to achieve an effect in lowering systolic and diastolic blood pressure to a standard value. This study aims to determine the effectiveness of therapy, and whether or not there is a difference in blood pressure between amlodipine and nifedipine treatment. The type of research is analytic observational, with retrospective data collection conducted at Tanjungsari Health Center, Pacitan, East Java. The study subjects were control outpatients for the period January-September 2021 and met the inclusion criteria (ICD-110 outpatient hypertension patients, age 20 years, male or female with or without other diseases, receiving amlodipine and nifedipine antihypertensives, minimal treatment 3 months). The effectiveness of therapy is measured by the percentage of patients whose blood pressure values reach the therapeutic target after 3 months. The results of the study were 99 patients who met the inclusion criteria, 51 patients on amlodipine therapy with 73?fectiveness and 48 patients on nifedipine therapy with 29?fectiveness. The mean systolic blood pressure after 3 months of amlodipine therapy was 137 mmHg and 154 mmHg for nifedipine therapy. The mean diastolic blood pressure after 3 months of amlodipine therapy was 83 mmHg and 87 mmHg for nifedipine therapy. There was a significant difference in mean systolic blood pressure (p=0.000) and mean diastolic blood pressure (p=0.001) in hypertensive patients treated with amlodipine and nifedipine. In conclusion, the therapeutic effectiveness of amlodipine was 73% and nifedipine was 29%, and there was a significant difference (p<0.01) in blood pressure from amlodipine and nifedipine treatment.

URL:
http://103.158.96.210:88/web_repository/uploads/9914-29208-1-PB.pdf

Type:
Procceding

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
Alfian Aji Wicaksono