Description:
Silver nanoparticles are known to be able to penetrate the cell membranes of acne-causing bacteria and cause structural damages that result in bacterial cell death. Silver nanoparticles need to be formulated in the form of a gel to make it easier to use. This study was conducted to synthesis the silver nanoparticles and to formulate it in the form of gel. The synthesis of silver nanoparticles was carried out using the chemical reduction method with sodium citrate as a reducing agent and gelatin as a stabilizer solution. The characterization results of silver nanoparticles obtained a maximum wavelength of 430.2 nm, absorbance of 0.297, particle size of 157.73±15.03 nm, polydispersity index of 0.328±0.032, and spherical morphology. Silver nanoparticles were formulated in gel preparations with variations concentrations of HPMC 7%, 10%, and 15%. Formula 3 with 15% HPMC as novelty of this finding showed the best test and analysis results compared to the other two formulas with physical characteristics in the form of a viscosity value of 3931.75 ± 92.383 cps, a spreading diameter of 6.41 ± 0.06 cm and a spreadability of 22.78 ± 0.221 g.cm /second, adhesion 59.43 ± 1.158 seconds, and the pH value of 5.81 ± 0.04. This study resulted in a new gel nanoparticle formula that meets the requirements of gel physical properties so that it can help the use of silver nanoparticles as an anti-acne

URL:
http://103.158.96.210:88/web_repository/uploads/35343-147138-2-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
CITRA ARIANI EDITYANINGRUM