Description:
Self-emulsifying drug delivery systems (SEDDS) were developed as a method to increase lipophilic drug solubility such as ibuprofen, and to increase the absorption and rate of drug dissolution. Therefore, the purpose of this study is to develop a new pharmaceutical dosage qualified ibuprofen SEDDS formulation and to increase ibuprofen bioavailability. The SEDDS formula was obtained from the ibuprofen solubility test and the optimization of the formula on various concentrations of oils, surfactants and cosurfactants. Oleic acid, cremophor RH 40 and propylenglycol respectively use as oil, surfactant and cosurfactant with comparison of oil phase:(surfactant + cosurfactant) 1:9 and comparison of surfactant: cosurfactant (3:2). Evaluations of the optimum SEDDS formula included transmittance percentage measurement, dispersibility test, robustness test, stability test, particle size measurement and dissolution rate test. The best ibuprofen SEDDS formula have met requirement of transmittance percent (99.7±0.872%), dispersibility test (41.48±1.3 seconds), the SEDDS formula was stable on the robustness test, no separation of phase in stability test and globule size in the micrometer range of 114.7±0.692 nm. The in vitro dissolution rate test results at the 10th minute showed that the ibuprofen SEDDS preparation was higher than the pure ibuprofen powder, namely 90.04 ± 1.764% and 59.33 ± 1.638%, respectively

URL:
http://103.158.96.210:88/web_repository/uploads/31508-147149-2-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
FITRIANTI DARUSMAN