Description:
The ability of an active pharmaceutical ingredient to be compressed is directly affected by its mechanical properties, such as flowability and tabletability. The characterization of the co-crystal formation included crystal morphology, powder X-ray diffractogram, and thermal behavior. The mechanical properties testing including flowability (compressibility index) and tabletability (tensile strength and elastic recovery) were conducted on DXI-CAF co-crystal and pure DXI. The tabletability test was conducted at 10-60 kg/cm2 of compression force. The characterization results show that the USSC result has a unique crystal habit, diffractogram, melting point that is different from pure DXI, and this indicates the formation of DXI-CAF co-crystal. The DXI-CAF co-crystal compressibility index was in the good category, while pure DXI was in the poor category. The maximum tensile strength value of the DXI-CAF co-crystal was 1.526 MPa achieved at a compression force of 50 kg/cm2 , whilst the maximum tensile strength value of pure DXI was only 0.853 MPa achieved at a compression force of 20 kg/cm2 . The elastic recovery curve showed the percentage of elastic recovery of DXI-CAF cocrystal was better than pure DXI. It can be concluded that the co-crystal formation of DXI-CAF by the USSC method can improve the mechanical properties of dexibuprofen.

URL:
http://103.158.96.210:88/web_repository/uploads/34713-138624-3-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
FIKRI ALATAS