Description:
There are many medicinal plants have been recognized as sources of natural antimicrobial compounds that are used as potentially effective alternatives in the treatment of bacteria. Clerodendrum have been investigated for it is antimicrobial activity in some bacteria. The aim of this study is to determine antimicrobial activity of n-hexane and water fraction of pagoda (Clerodendrum paniculatum) leaves against Pseudomonas aeruginosa and Metichilin Resistant Staphylococcus Aureus (MRSA). The antimicrobial activity of the isolated compound was performed by disc diffusion method. N-hexane fraction of Clerodendrum paniculatum have antimicrobial activity to Pseudomonas aeruginosa with inhibition 9.43 ± 0.057; 8.76 ± 0.057; 8.17 ± 0.115; 7.03 ± 0.057 and to MRSA 6.07 ± 0.057; 6.03 ± 0.057; 6.03 ± 0.115; 6.03 ± 0.057 in concentration 300 ppm, 200 ppm, 100 ppm and 50 ppm. Water fraction of Clerodendrum paniculatum have antimicrobial activity to Pseudomonas aeruginosa with inhibition 9.13 ± 0.057; 8.30 ± 0.100; 7.86 ± 0.057; 6.53 ± 0.057 and to MRSA 8.50 ± 0.100; 7.73 ± 0.057; 6.87 ± 0.057; 6.47 ± 0.057 in concentration 300 ppm, 200 ppm, 100 ppm and 50 ppm. This showed n-hexane and water fraction of Clerodendrum paniculatum has potential as a novel antimicrobial.

URL:
http://103.158.96.210:88/web_repository/uploads/30659-138621-2-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
DEWI PERTIWI