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Hansen Solubility Parameters: A Tool for Solvent Selection in Drugs



Description:
Hildebrand1 defined the solubility parameter as measures the contribution to the solubility of the cohesive energy density. Then, Hildebrand solubility parameter is calculated from the square root of the cohesive energy density, which is a characteristic of the intermolecular interactions in a compound. Subsequently, total solubility parameter of Hildebrand (?T 2 ) was divided into the contribution of several partial parameters, so that they can be applied to polar systems. Several authors have proposed dividing the total solubility parameter into partial solubility parameters. Nevertheless, perhaps it was Hansen in 19672 who achieved a more exact approximation for the calculation of partial solubility parameters (Eq. 1).

URL:
http://103.158.96.210:88/web_repository/uploads/ps-29-133.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
María Á. Peña