Description:
Infectious disease is one of the causes of death in the world. Antibiotics are often used in the treatment of bacterial infections but are currently experiencing resistance. Based on this, the search for alternative antibiotics from natural sources needs to be done, one of which is from fungi. Fungi are eukaryotic microbes which have been an eminent sources for many currently available antibiotics including penicillin. This study was conducted to determine the potential antibacterial activity of ethyl acetate extract of estuarine fungi isolates against gram-positive, Staphylococcus aureus bacteria. Phytochemical screening of the extract using the TLC method while antibacterial testing was carried through a standard microdilution protocol. Antibacterial activity was reported in percent inhibition. The antibacterial test resulted in seven extracts possessed significant activity, with the highest percent inhibition of the IS-IB-T2 isolate code is 66.5 ± 1.1% and the lowest of the IS-IB-B2 isolate code is 12.2 ± 0.7% at concentration of 100 µg/mL. Majority compounds detected in each extract was terpenoids which suggested the contribution of antibacterial mechanisms. Therefore, estuary soil fungi have the potential to be further explored by antibiotic compounds.

URL:
http://103.158.96.210:88/web_repository/uploads/28834-138615-2-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
AFRIAN ROSYADI