Description:
Prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) can trigger ulcers in the gastric mucosa. Pepolo stem bark (Bischofia javanica Blume) has been empirically used to treat gastric ulcers. This plant contains alkaloids, flavonoids, tannins, saponins, and triterpenoids with gastroprotective potential. This study aims to determine the gastroprotective effect of pepolo stem bark extract (PSBE) against gastric ulcers of Wistar rat induced by Aspirin. Aspirin (150 mg/kg BW) was administered orally for eight days to all the groups except normal control. After 4 h of induction, normal and negative control received Na CMC 0.5%, while the positive group received Omeprazole (3.6 mg/kg BW). The remaining low, middle, and high dose groups received PSBE (100, 200, and 300 mg/kg BW). On the 9th day, the rats were dissected and tested on the stomach organs. The parameters were scored based on the severity of rat peptic ulcers, ulceration index, and percentage protection ratio. The scoring data were analyzed using the Kruskal-Wallis non-parametric test and post hoc the Mann-Whitney test. The administration of PSBE showed the ability to reduce the ulcer index and increase the percentage of ulcer inhibition significantly compared to the negative control (p<0.05), thus showed that PSBE could be a promising gastroprotective herbal medicine

URL:
http://103.158.96.210:88/web_repository/uploads/35452-131367-1-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
YULIET SUSANTO