Description:
The use of alternative medicine, especially medicinal plants to treat various diseases including hyperlipidemia has increased over the last few decades in most countries around the world. Bitter melon (Momordica charantia) contains active ingredients such as flavonoids, tannins, saponins and polyphenols which have antihyperlipidemic effects. The study aims to determine the antihyperlipidemic effect of bitter melon aqueous extract and compare it with simvastatin in reducing total cholesterol and lowdensity lipoprotein (LDL), and increasing high-density lipoprotein (HDL) in male Wistar strain rats. The research is an experimental study with pre and post-test design, carried out in October-December 2021 at the Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi Indonesia. Subjects consisted of 25 Wistar rats which were divided into five groups. The negative control group (standard diet), the positive control group (induced by a high-fat diet and propylthiouracil), and the three groups that were induced by a high-fat diet and propylthiouracil then given bitter melon extracts of 300 and 600 mg/ kg BW and simvastatin 10 mg/kg BW. The method of measuring cholesterol using the Cholesterol Oxidase-Perioxidase Aminoantipyrine (CHOD-PAP) enzymatic method principle with a Semi-automatic Chemistry Analyzer. Analysis using paired t-test. The results showed a significant difference (P<0.005) in HDL and total cholesterol levels in the 600 mg/kg BW dose group, and a significant difference in LDL level in the 300 mg/kg BW dose group. The Simvastatin group showed significant differences in HDL, LDL, and total cholesterol. This is presumably because the active substances in bitter melon can inhibit the HMG-CoA reductase enzyme so that it can reduce LDL and total cholesterol levels. It can be concluded that bitter melon aqueous extract at doses 300 and 600 mg/Kg BW can reduce total and LDL cholesterol levels, and increase HDL.

URL:
http://103.158.96.210:88/web_repository/uploads/38980-194108-2-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
Evi Sovia