Description:
Ethanol extract of Piper crocatum leaves has inhibitory activity of ?-glucosidase enzyme. Ethyl acetate fraction from Piper crocatum leaves has the highest antioxidant activity and has an inhibition of ?-glucosidase containing 6XO32ZSP1D, Ethyl L-serinate hydrochloride compound, Schisandrin B compound, Columbin compound, 4-(4-methoxy-phenylamino)-2 compound, 3-dihydro-1H-4a, 9-diazacyclopenta (b) fluorine-10-carbonitrile, compound 6-Amino-4-[3-(benzyloxy)phenyl] -3-tertbutyl-2,4-dihydropyrano [2, 3-c] pyrazole-5-carbonitrile, compound 4-{{4.6-Bis [(3R, 5S)-3,5-diamino1-piperydinyl] -1,3,5-triazine-2-yl}amino) benzenesulfonamide and compound 1.1'-(1,4-butanediyl) bis {2,6-dimethyl-4-[(3-methyl-1,3-benzothiazol-2(3H) ylidene) methyl]pyridinium. This study aims to obtain the interaction between bioactive compounds contained in ethyl acetate fraction of Piper crocatum leaves with ?-glucosidase enzyme in In Silico using AutoDock Vina, Columbin shows the lowest binding energy with binding sites with amino acids Ser240, Asp242, His280, Arg315, Glu411, Phe159, Arg442, Tyr158 and Phe303. Columbin has the stability and inhibits the ?-glucosidase enzyme from S. cerevisiae better than the seven other compounds, because it has OH and CH3 groups which play a role in the interaction with around the active side of the ?-glucosidase enzyme.

URL:
http://103.158.96.210:88/web_repository/uploads/21120-92269-1-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
MUSTIKA WENI