Description:
Context: Alzheimer's disease (AD) is one of the biggest causes of public health problems today, especially in older, where women have a greater risk of developing AD than men. However, the current AD therapy has not been satisfactory. Nigella sativa(NS) has bioactive compounds of flavonoid compounds and estrogenic effects that could be alternative medicine. Aims: To evaluate an extract of N. sativa on improving memory function through reducing GSK3? activation and A?42/40 ratio in a model of AD in rats. Methods: This research was an experimental study with the post-test-only group design using 24 Wistar rats divided into eight groups. Conjugated equine estrogen (CEE) 0.018-0.0036 mg/day and NS 100, 200, and 400 mg/kg BW were administered orally two weeks before intraperitoneal AlCl3 induction, then continued for up to 8 weeks. In the last five days of the study, the Morris water maze memory test was performed to analyze the expression of amyloid ? (A?), neurofibrillary tangles (NFT), glycogen synthase kinase 3? (GSK3?), and A?42/40 ratio. Results: There were significant differences in the memory test (p = 0.000), the expression A?40 (p = 0.000), A?42 (p = 0.000), NFT (p = 0.000) and GSK3? levels (p = 0.000). The lowest expression of A?40 in the NS100 group, A?42 in the NS400, NFT in the CEE group, and GSK3? levels in the NS100 group. Administration of NS increased the plasma ratio of A?42/40 with the highest mean in the CEE group (p = 0.001). Conclusions: The administration of NS extract affected improving memory function by decreasing the expression of A?, NFT, GSK3? in ovariectomized Wistar rats supplemented with AlCl3.

URL:
http://103.158.96.210:88/web_repository/uploads/jppres21.1211_10.2.328.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
Kusuma Andriana