Description:
Context: Periodontitis causes pocket formation, gingival recession, and destruction of periodontal ligaments and alveolar bone. Periodontitis disturbs the attachment of periodontal ligaments to the maxillary and mandibular bones. The ?-mangostin has shown role-playing in the bone remodeling process. Aims: To evaluate the potential of ?-mangostin induce the TGF?1 titer associated with the increased mandibular bone volume on the alveolar bone remodeling of periodontitis of Rattus novergicus. Methods: The ?-mangostin used to the single administration dosage on the rat periodontitis model on the 7 and 14 days. TGF-?1 titer tested by enzyme-linked immunosorbent assay, while the X-Ray Micro-CT/Micro Computed Tomography examined the volume's development of the mandibular bone. Results: At the 7 days, 0.5 and 1% of ?-mangostin had a better effect to increase the bone volume, and TGF-?1 titer has linearity of bone development at concentrations of 0.5 to 2%. At 14 days, 1 and 2% of ?mangostin exhibited a better effect on inducing an increase in mandibular bone volume and TGF-?1 titer. The linearity of both occurs at concentrations of 0.5 to 1%. The Micro-CT of the mandibular bone showed callus or new bone formation at the edge of each treatment group's lesion as an indicator of bone remodeling. Conclusions: ?-Mangostin induced an increase in the TGF-?1 titer, which was in line with the rise in the volume of the mandibular bone of Rattus novergicus.

URL:
http://103.158.96.210:88/web_repository/uploads/jppres21.1015_9.5.609.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
Citra Lestari