Description:
Objective: This research aimed to determine the effect of variations in the concentration of filler agents Avicel PH 102-Ludipress on the evaluation results of granules and tablets and to determine the antioxidant activity of ciplukan (Physalis angulata L.) fruit extract lozenges. Methods: The extract was obtained by the soxhletation method using ethanol 96%. The lozenges were made by direct compression, and the formula was divided into 3 concentration variations of Avicel PH 102 and Ludipress, namely F1 (1:2), F2 (1:1), and F3 (2:1). The best lozenges were tested for their antioxidant activity using the DPPH method. Results: The results of statistical analysis using the One Way Anova test formulation of ciplukan fruit extract lozenges with variations in concentrations of Avicel PH 102 and Ludipress had a significant effect (p<0>0.05) on diameter, weight variation, and hardness. The best ciplukan fruit extract (F1) lozenge formula has a concentration ratio of Avicel PH 102 and Ludipress (1:2) with an IC50 value of 28.46 ppm and is classified as a very strong antioxidant. Conclusion: Ciplukan fruit extract formulated in the form of lozenges with varying concentrations of the filler Avicel PH 102: Ludipress (1:2) has very strong antioxidant activity.

URL:
http://103.158.96.210:88/web_repository/uploads/LOZENGES_FORMULATION_OF_CIPLUKAN_(PHYSALIS_ANGULATA_L.)_FRUIT_EXTRACT_AS_AN_ANTIOXIDANT_WITH_COMBINATION_OF_FILLER_AGENTS_AVICEL_PH_102–LUDIPRESS1.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
03-07-2024

Author:
Dr. apt. Yenni Puspita Tanjung, M.Farm.