Description:
Green grass jelly (Premna oblongifolia Merr.) is abundant in Indonesia and is a traditional Indonesian food. Moreover, this plant is rich in fiber and antioxidant properties. The research aims to determine the influence of ethanol extract from green grass jelly leaves on gastric ulcer healing and the optimal composition of mucoadhesive granules. The Wistar rats were grouped into negative control, positive control, and three test dose groups. Treatment was administered for three days, and peptic ulcers were scored based on the quantity and severity of the lesions. Statistical comparisons between treatment groups were conducted using a one-way ANOVA test. The results showed that the third dose group exhibited the best activity in healing gastric ulcers compared to the negative control group, with wound healing percentages of 12.13% (p 0.024), 20.93% (p 0.004), and 24.47% (p 0.000) for test 1, test 2, and test 3, respectively. Therefore, it can be concluded that the ethanol extract of green grass jelly leaves at test dose 3 is chosen as the optimal dose for peptic ulcer treatment. Moreover, the best formulation is found in Formula 3.

URL:
http://103.158.96.210:88/web_repository/uploads/50688-201411-1-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
TITA NOFIANTI