Description:
Domperidone shows low bioavailability values when administered orally so this compound is suitable for administration transdermally Penetration enhancer was one component that can increase the diffusion of domperidone which was formulated in patch preparations. The aim of the study was to compare the penetration-enhancing ability of isopropyl myristate (IPM) and eucalyptus oil (EO) on the diffusion profile of the domperidone patch (DP). DP was made by solvent casting method using hydroxyl propyl methyl cellulose (HPMC) and penetration enhancer (IPM and EO) with concentrations of 2%, 5%, and 10%, respectively. DP evaluations carried out were organoleptic, weight uniformity, thickness, moisture content, drug content, and diffusion. DP had the appearance of a round shape with a diameter of 0.9 cm, white, dry, and not cracked. The results of the diffusion profile showed that the diffusion kinetics of DP-IPM and DP-EO were zero order, and the rate of diffusion of DP-IPM ranges from 31.448-37.612 ppm/hour while DP-EO ranges from 30.102-35.394 ppm/hour. The conclusion was that penetration enhancers (IPM and EO) do not affect the diffusion kinetics of PD, but the diffusion rate of DP-IPM is higher than DP-EO.

URL:
http://103.158.96.210:88/web_repository/uploads/50400-201414-1-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
RAHMAH ELFIYANI