Description:
Turmeric contains curcuminoid compounds which have been confirmed from various studies to have various benefits for the body, including antiviral, antibacterial, antioxidant, anticarcinogenic, and anti-inflammatory properties. Research on the effectiveness and potential of anti-inflammatory properties of the compounds contained in turmeric was carried out based on in silico and in vitro studies. Methods used are prediction of physicochemical and pharmacokinetic properties, molecular docking, pharmacophore modeling, and toxicity testing using the BSLT method. The results obtained all the test compounds complied with the Lipinski rules of five, but some of the test compounds were mutagens and carcinogens. A compound with high anti-inflammatory potential is dihydrocurcumin, which has a binding energy of -8.25 kcal/mol, Ki of 0.898 µM, and hydrogen bonds similar to those formed between native ligand and COX-2 protein. Based on the results of the BSLT, it was found that the turmeric infusion extract had toxic protectives thus it has a poor potential as an anti-inflammatory for dysmenorrhea.

URL:
http://103.158.96.210:88/web_repository/uploads/47171-182882-2-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
DEVANI O WINARDI