Description:
Apigenin (4`,5,7-trihydroxyflavone) is a flavonoid of subclass flavones that have antidiabetic therapeutic activity but limitations BCS Class II low solubility of 2.16 ?g/L. To overcome these limitations, the development of nanoemulsion formulation technology, increasing solubility increases dissolution, absorption and bioavailability. It is incorporated into the buccal film for easy application and direct access to the systemic circulation. This study aims to obtain apigenin nanoemulsion with the best characterization and buccal film that meets the characterization. The method was carried out experimentally in the manufacture of nanoemulsions by spontaneous emulsification, a buccal film by solvent casting, and the characterization. 10 nanoemulsion formulas met the characterization with globule size <20.34nm, polydispersity index <0.131, zeta potential close to 0mV, pH 6.23- 6.59, %transmittance close to 100% and best F10 incorporated into buccal film has 29x the solubility compared to apigenin with p?0.05. All buccal films met the characterization with F3 having a 2x faster onset of release than F1&F2 with 86.07% diffusion and 97.9333 mg/sheet. Thus, it was concluded that the formulation and characterization of buccal film fulfilled the characterization and F10 apigenin nanoemulsion increased the solubility 29-fold with the buccal film F3 having a faster onset of release.

URL:
http://103.158.96.210:88/web_repository/uploads/42829-163117-1-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
LUSI NURDIANTI