Description:
Cinchona extract contains quinoline alkaloids, has telangiectatic activity, is practically insoluble in water so penetration into hair follicles is low, and requires a delivery system, namely cream. Purposed to determine the formula of cinchona extract cream which has good activity, physical stability, and safety. Cinchona bark extraction (soxhletation method), phytochemical screening, cinchona extract dosage determination, optimization of a cream formula using Design-Expert software version 11. Activity test using guinea pigs (Cavia porcellus) and acute dermal irritation test using rabbit (Orycogalus cuniculus). Cinchona extract (13.32% yield) contained quinoline alkaloids, cinchona extract dosage was 20% (p<0.05). The optimum formula on F2 with characteristics: pH 6.48±0.07, adhesion 1.16±0.07, spreadability 4.99±0.85, and viscosity 3067±416.45 has good physical stability. Activity test: test area hair length 13.54 – 62.14% longer than normal control and 10.10 – 49.17% than the negative control. The hair mass of the test area was 122.91% heavier than the normal control and 104.48% of the negative control (p<0.05). Cinchona extract and excipients were non-irritant. Cinchona extract cream (20%) has hair fertilizer activity, good physical stability, and safety.

URL:
http://103.158.96.210:88/web_repository/uploads/36324-133939-1-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
HARIYANTI