Description:
Cincalok is a fermented shrimp product which has the potential to be used as pharmaceutical preparations. LD50 test results indicate that the substance is practically non-toxic. However, subchronic toxicity tests have not been performed. Therefore, this study aims to determine its subchronic toxicity assay towards haematology in male and female rats in the Wistar strain. The animals used were divided into six groups: the control group induced with virgin coconut oil (VCO), the treatment groups induced with Cincalok oil (100, 400, and 1000 mg/kgbw), satellite control group induced with VCO and the satellite control group induced with a dose of 1000 mg/kgbw. Haematological parameters evaluated include hemoglobin, red blood cells (RBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), leukocytes, basophils, lymphocytes, eosinophils, platelets, and neutrophils. The average level of the haematological profile indicated that hemoglobin, RBC, MCH, MCHC, basophils, eosinophils, stem neutrophils, neutrophil segments, lymphocytes, leukocytes, monocytes, and platelets in female and male rats were still in the normal range. While there was a decrease in levels below the normal range in the parameters of MCV (in female rats) and hematocrit (in male rats), it was reversible.

URL:
http://103.158.96.210:88/web_repository/uploads/43023-203490-3-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
FAJAR NUGRAHA