Description:
Curcumin is a compound from the turmeric rhizome plant (Curcuma longa) which has immunostimulating activity. This activity has been tested pre-clinically in vitro, in vivo, and in silico so that it has the potential to be used as raw material for drugs in the development of new drugs to prevent the SARS-CoV 2 virus. The purpose of this study was to examine the immunostimulatory activity of turmeric in vitro, in vivo, and in silico and to explore the mechanism of curcumin compounds as immunostimulants. The method used in this systematic review is Systematic-Meta Analysis by identifying articles from several journal databases (GoogleScholar, ResearchGate, ScienceDirect, Garuda Dikti). Furthermore, the article selection process used a guideline prism flow chart. From this process, it was found 15 articles as the main reference, 5 articles containing in vitro research, 5 articles in vivo, and 5 articles in silico from the turmeric rhizome plant. In vitro preclinical tests show that curcumin compounds have an immunostimulating effect which is characterized by the occurrence of proliferation and activation in several types of immune system cells. In vivo study was proven by an increase in phagocytic activity and an increase in leukocyte production in experimental animals. Whereas in silico was proven by the binding of various SARS-CoV 2 receptors.

URL:
http://103.158.96.210:88/web_repository/uploads/Systematic_Review_Potential_of_Curcumin_Compounds_as_Immunostimulants_in_the.pdf

Type:
Procceding

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
Burhan Ma’arif