Repository Akfar Bumi Siliwangi
Formulation and Characterization of SNEDDS of Dayak Onion Extract with Comparative Variation of Surfactants, Co-Surfactants, and Palm Oil
Description:
Self-Nanoemulsifying Drug Delivery System (SNEDDS) is a thermodynamically stable drug
administration unit with the capacity to increase the solubility of active pharmaceutical ingredients (API)
and bioavailability. In addition, dayak onion extract is an active ingredient developed to increase the
effectiveness of therapy. The aims to formulate, characterize, and investigate stability. Moreover, the
HLB approach was used to formulate SNEDDS from dayak onion extract, with a component ratio of palm
oil, a combination of surfactants (hydrophilic Tween 80, Tween 20) and lipophilic (Span 20 and
Transcutol) and PEG 400 as co-surfactants. A total of sixty formulas were used, with an HLB range of
11-15 and a ratio of 1:8:1, 1:7:2, and 2:7:1, followed by evaluating product characteristics. Furthermore,
two formulas were selected, including F13 (HLB 13) and F34 (HLB 14), at ratios 1:8:1 and 1:7:2. The
results showed particle size ranging from 10-200 nm, percent transmittance of <90%, while the viscosity
and pH values were stable at various dilutions. The evaluation for thermodynamics indicates an unstable
preparation. Therefore the SNEDDS formula of dayak onion extract using long-chain triglycerides (palm
oil) was ineffective.
Type:
Procceding
Document:
Diploma III Farmasi
Date:
23-06-2024
Author:
Rahmi Annisa