Description:
The anti-inflammatory of B. javanica needs to be made into a topical preparation. The bioavailability and stability of the active substance is a limitation in its use thus it is necessary to develop an appropriate formula. Nanoemulsion can increase stability and penetration of drugs to pass the skin barrier. This study conducted to determine the formulation of B. javanica seed ethanol extract nanoemulsion and its stability. The formulation was carried out using a pseudoternary phase diagram with 3 variations of components olive oil (EVOO), Smix (tween-propylene glycol 5:1), and water. The charachterization of nanoemulsi were globule size, % transmittant, pH, viscosity, and drug load. The nanoemulsion of B. javanica seed extract was evaluated for stability using the Freeze-thaw method. The characteristics of the nanoemulsion preparations obtained were globule size of 14.4±0.3 nm, zeta potential of 7.7±0.2 mV, %transmittant of 93.05±4.06%, pH of 7.14±0.05, viscosity of 35800±2700 cps, and drug load of 83.81±8.49%. The noverlty of this study that nanoemulsion of B. javanica seed extract has good characteristics, but unstable for transmittant and zeta potensial

URL:
http://103.158.96.210:88/web_repository/uploads/38691-204979-2-PB.pdf

Type:
Journal

Document:
Diploma III Farmasi

Date:
23-06-2024

Author:
WAHIDA HAJRIN